The Hughes-Fulford Laboratory, directed by Dr. Millie Hughes-Fulford, is located in the Veterans Affairs Medical Center, San Francisco, CA. The goal of our laboratory is to understand the mechanisms which regulate mammalian cell growth.
Growth is induced by altering cell signaling and gene expression. The stimulation can be caused by growth factors, cytokines (including lipids and biolipids) or mechanical stress. Mastery of this knowledge could help those suffering from diverse diseases ranging from osteoporosis (lack of stimulation of the osteoblast growth ) to cancer (inappropriate upregulation of tumor cell growth).
We have several on-going research projects, which include investigating the role of dietary fatty acids in prostate cancer cell growth, the response of osteoblasts to mechanical loading and the signal transduction cascades and gene expression occurring during T-cell activation.